Publications

N. Chofflet, Y. Naito, A.J. Pastore, N. Padmanabhan, P.T. Nguyen*, C. Poitras, B. Feller, N. Yi, J. Van Prooijen, H. Khaled, B. Coulombe, S. Clapcote, S. Bourgault, T.J. Siddiqui, G. Rudenko, H. Takahashi. (2024). Structural and functional characterization of the IgSF21-Neurexin 2α complex and its related signaling pathways in the regulation of inhibitory synapse organization. Frontiers in Molecular Neuroscience. 17: 1371145.

Kihal N., Nguyen P.T., Nazemi A., Greschner A.A., Gauthier M.A., Bourgault S. (2024). DNA nanostructures prevent the formation of and convert toxic amyloid proteospecies into cytocompatible and biodegradable spherical complexes. Aggregate. e502(doi.org/10): 1-14.

Bokros M., Balukoff N.C., Grunfeld A., Sebastiao M.*, Beurel E., Bourgault S., Lee S. (2024). RNA tailing machinery drives amyloidogenic phase transition. Proceedings of the National Academy of Sciences (PNAS). 121(23): e2316734121.

Calzas C., Alkie T.N., Suderman M., Embury-Hyatt C., Khatri V.*, Le Goffic R., Berhane Y., Bourgault S., Archambault D., Chevalier C. (2024). A vaccinal strategy based on the use of M2e nanoparticles combined with HA1domain of hemagglutinin fully protects chickens against challenge with a heterologous highly pathogenic avian influenza H5N1 virus. NPJ Vaccines. 9(161): 1-13.

Bérubé F., Bousch C., Babych M.*, Ongeri S., Bourgault S. (2024). Molecular mechanisms of amylin aggregation: chemical strategies to arrest amyloid self-assembly and to design non-aggregating peptide therapeutics. Frontiers in Molecular Biosciences. N/A: N/A.

St-Louis P., Martin C., Khatri V.*, Bourgault S., Archambault D. (2024). Intranasal delivery of a selfadjuvanted nanovaccine composed of the curli filaments and the highly conserved M2e epitope confers protection against influenza a virus in mice. Vaccine. 42(9): 2144-2149.

Archambault M-J., Mwadi L., Côté-Cyr M.*, Bourgault S. (2024). Nanoparticles as delivery systems for antigenic saccharides: from conjugation chemistry to vaccine design. Vaccines.

Kihal N., Archambault M.J., Babych M.*, Nazemi A., Bourgault S. (2024). Probing the molecular determinants of the activation of toll-like receptor 2/6 by amyloid nanostructures through directed peptide self-assembly. Soft Matter. 20(39), 7821-7831.

Ye D., Nguyen P.T.*, Bourgault S., Couture M. (2024). The heme binding protein ChuX is a regulator of heme degradation by the ChuS protein in Escherichia coli O157:H7. Journal of Inorganic Biochemistry. 256:112575.

Babych M., Garelja M.L., Nguyen P.T., Hay D.L., Bourgault S. (2024). Converting the amyloidogenic islet amyloid polypeptide into a potent non-aggregating peptide ligand by side chain-to-side chain macrocyclization. Journal of the American Chemical Society (JACS). 146(7): 25513-25526.

Feller B., Fallon A., Luo W., Nguyen P.T.*, Shlaifer I., Lee A.K., Chofflet N., Yi N., Khaled H., Karkout S., Bourgault S., Durcan T.M., Takahashi H. (2023). α-synuclein preformed fibrils bind to β-neurexins and impair β-neurexin-mediated presynaptic organization. Cells. 12(7): 1083.

Sebastiao M., Babych M., Quittot N.*, Kumar K., Arnold A.A., Marcotte I., Bourgault S. (2023). Probing the kinetics of membrane perturbation induced by amyloidogenic peptides in biologically relevant environments using cell plasma membrane vesicles. BBA – Biomembranes. 1865(3): 184118.

Khalifa J.*, Bourgault S., Gaudreault R. (2023). Interactions of Polyphenolic Gallotannins with
Amyloidogenic Polypeptides Associated with Alzheimer’s Disease: From Molecular Insights to Physiological Significance. Current Alzheimer Research. 20(9): 603-617.

Bricha S., Côté-Cyr M., Tremblay T., Nguyen P.T., St-Louis P., Giguère D., Archambault D., Bourgault S.*. (2023). Synthetic Multicomponent Nanovaccines Based on the Molecular Co-Assembly of β-Peptides Protect Against Influenza A Virus Infection. ACS Infectious Diseases. 9(6): 1232-1244.

Bélanger-Bouliga M., Mahious H., Nguyen P.T.*, Bourgault S., Nazemi A. (2023). Synthesis and
Characterization of Tetraphenylethylene-Functionalized N-Heterocyclic Carbene Stabilized Gold Nanoparticles with Aggregation-Induced Emission. Canadian Journal of Chemistry. 101(7): 477-486.

Sebastiao M., Quittot N., Marcotte I., Bourgault S. (2023). Fluorescence Resonance Energy Transfer to Detect Plasma Membrane Perturbations in Giant Plasma Membrane Vesicles. Bio-protocol. 13(19): 1-14.

Wiebe H., Nguyen P.T.*, Bourgault S., van de Ven T.G.M., Gaudreault R. (2023). Adsorption of Tannic Acid onto Gold Surfaces. Langmuir. 39(16): 5851–5860.

Kihal N., Côté-Cyr M., Nazemi A., Bourgault S. (2023). Semiconductive and Biocompatible Nanofibrils from the Self-Assembly of Amyloid p-Conjugated Peptides. Biomacromolecules. 24(3): 1417-1431.

Lamontagne F., Arpin D., Côté-Cyr M., Khatri V., Gauthier L., Archambault D., Bourgault S. (2023). Engineered Curli Nanofilaments as a Self-Adjuvanted Antigen Delivery Platform. Advanced Healthcare Materials. 12(21): 2300224.

Khatri V.*, Jafari M., Beauregard M., Gaudreault R., Archambault D., Siaj M., Loranger É., Bourgault S. (2023). Bionanocomposites with Enhanced Physical Properties from Curli Amyloid Assemblies and Cellulose Nanofibrils. Biomacromolecules. 24(11): 5290-5302.

Côté-Cyr M., Zottig X., Gauthier L., Archambault D., Bourgault S. (2022). Self-Assembly of Flagellin into Immunostimulatory Nanoring Structures as Antigen Delivery System. ACS Biomaterials Science & Engineering. 8(2): 694-707.

Kumar K., Sebastiao M.*, Arnold A.A., Bourgault S., Warschawski D.E., Marcotte I. (2022). In Situ Solid-State NMR Study of Antimicrobial Peptide Interactions with Erythrocyte Membranes. Biophysical Journal. 121(8): 1512-1524.

Fortier M., Côté-Cyr M., Nguyen V., Babych M., Nguyen P.T.*, Gaudreault R., Bourgault S. (2022). Contribution ofthe 12-17 Hydrophobic Region of Islet Amyloid Polypeptide in Self-Assembly and Cytotoxicity. Frontiers in Molecular Biosciences. 9(1017336): 1-20.

Kihal N.*, Nazemi A., Bourgault S. (2022). Supramolecular Nanostructures Based on Perylene Diimide Bioconjugates: From Self-Assembly to Applications. Nanomaterials. 12(7): 1-22.

Haddad M., Gaudreault R., Sasseville G., Nguyen P.T.*, Wiebe H., Van De Ven T., Bourgault S., Mousseau N., Ramassamy C. (2022). Molecular Interactions of Tannic Acid with Proteins Associated with SARSCoV-2 Infectivity. International Journal of Molecular Sciences. 23(5): 2643.

Côté-Cyr M., Gauthier L., Zottig X., Bourgault S., Archambault D. (2022). Recombinant Bacillus subtilis flagellin Hagis a potent immunostimulant with reduced proinflammatory properties compared toSalmonella enterica serovar Typhimurium FljB. Vaccine. 40(1): 11-17.

Lamontagne F., Khatri V., St-Louis P*, Bourgault S., Archambault D. (2022). Vaccination Strategies based on Bacterial Self-Assembling Proteins as Antigen Delivery Nanoscaffolds. Vaccines. 10(11): 1920.